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Literature summary for 1.5.98.1 extracted from

  • Muskal, S.M.; Sliman, J.; Kokai-Kun, J.; Pimentel, M.; Wacher, V.; Gottlieb, K.
    Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway (2016), F1000Res., 5, 606 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
lovastatin
-
 Methanobrevibacter smithii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 Methanobrevibacter smithii
-
 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 Methanobrevibacter smithii ATCC 35061
-
 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?

Organism

Organism UniProt Comment Textmining
Methanobrevibacter smithii A5UMI1
-
-
Methanobrevibacter smithii ATCC 35061 A5UMI1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
-
 Methanobrevibacter smithii 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
-
 Methanobrevibacter smithii ATCC 35061 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?

Synonyms

Synonyms Comment Organism
coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase
-
 Methanobrevibacter smithii
methylene-H(4)MPT dehydrogenase
-
 Methanobrevibacter smithii
MTD
-
 Methanobrevibacter smithii

Cofactor

Cofactor Comment Organism Structure
coenzyme F420
-
 Methanobrevibacter smithii