Application | Comment | Organism |
---|---|---|
diagnostics | the enzyme may be a valuable biomarker of hepatocellular carcinoma diagnosis | Homo sapiens |
medicine | expression of DMGDH is decreased in hepatocellular carcinoma. the enzyme can be applied as valuable biomarker for both diagnosis and prognosis | Homo sapiens |
medicine | the enzyme is biomarker for both diagnosis and prognosis for hepatocellular carcinoma | Homo sapiens |
medicine | the enzyme may be a valuable biomarker of hepatocellular carcinoma diagnosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N,N-dimethylglycine + electron-transfer flavoprotein + H2O | Homo sapiens | - |
sarcosine + formaldehyde + reduced electron-transfer flavoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q9UI17 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | hepatocellular carcinoma | Homo sapiens | - |
hepatocellular carcinoma cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
LM3 cell | - |
Homo sapiens | - |
SMMC-7721 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N,N-dimethylglycine + electron-transfer flavoprotein + H2O | - |
Homo sapiens | sarcosine + formaldehyde + reduced electron-transfer flavoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DMGDH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression is decreased in hepatocellular carcinoma | down |
Homo sapiens | expression is decreased in hepatocellular carcinoma | down |
General Information | Comment | Organism |
---|---|---|
metabolism | the phosphorylation of Akt-308/473 is significantly suppressed when the enzyme is overexpressed | Homo sapiens |
physiological function | dimethylglycine dehydrogenase expression suppresses metastasis through the Akt signaling pathway | Homo sapiens |
physiological function | DMGDH suppresses migration, invasion and metastasis both in vitro and in vivo. In a DMGDH over-expressing cell line, the phosphorylation of Akt-308/473 is significantly suppressed | Homo sapiens |
physiological function | the enzyme suppresses metastasis in hepatocellular carcinoma | Homo sapiens |