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Literature summary for 1.5.8.3 extracted from

  • Porter, D.H.; Cook, R.J.; Wagner, C.
    Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver (1985), Arch. Biochem. Biophys., 243, 396-407.
    View publication on PubMed
Search for more literature for 1.5.8.3

Inhibitors

Inhibitors Comment Organism Structure
Methoxyacetate
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.32 1 sarcosine
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sarcosine + acceptor + H2O Rattus norvegicus acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate glycine + formaldehyde + reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sarcosine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus glycine + formaldehyde + reduced acceptor
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.065
-
 sarcosine
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD covalent bound FAD linked via 8a-position of the isoalloxazin ring to the imidazole N(3) of a histidine residue, structural homology between the amino acid sequence of the flavin-peptides Rattus norvegicus
tetrahydrofolate
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.26
-
 Methoxyacetate competitive Rattus norvegicus