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Literature summary for 1.5.8.2 extracted from
- Mechanistic studies on the dehydrogenases of methylotrophic bacteria. 1. The influence of substrate binding to reduced trimethylamine dehydrogenase on the intramolecular electron transfer between its prosthetic groups (1982), Biochem. J., 207, 233-239.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Tetramethylammonium chloride | noncompetitive inhibition | Methylophilus methylotrophus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe | 4Fe-4S-center | Methylophilus methylotrophus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trimethylamine + H2O + electron transferring flavoprotein | Methylophilus methylotrophus | physiological electron acceptor, biphasic reaction kinetic | dimethylamine + formaldehyde + reduced electron transferring flavoprotein | - |
? | |
| trimethylamine + H2O + electron transferring flavoprotein | Methylophilus methylotrophus W3A1 | physiological electron acceptor, biphasic reaction kinetic | dimethylamine + formaldehyde + reduced electron transferring flavoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methylophilus methylotrophus | - |
- |
- |
| Methylophilus methylotrophus W3A1 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Methylophilus methylotrophus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Methylophilus methylotrophus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trimethylamine + H2O + electron transferring flavoprotein | physiological electron acceptor, biphasic reaction kinetic | Methylophilus methylotrophus | dimethylamine + formaldehyde + reduced electron transferring flavoprotein | - |
? | |
| trimethylamine + H2O + electron transferring flavoprotein | physiological electron acceptor, biphasic reaction kinetic | Methylophilus methylotrophus W3A1 | dimethylamine + formaldehyde + reduced electron transferring flavoprotein | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Methylophilus methylotrophus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| electron transferring flavoprotein | - |
Methylophilus methylotrophus | |
| FMN | - |
Methylophilus methylotrophus | |
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Release 2023.1 (January 2023)
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