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Literature summary for 1.5.5.3 extracted from

  • Cooper, S.K.; Pandhare, J.; Donald, S.P.; Phang, J.M.
    A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species (2008), J. Biol. Chem., 283, 10485-10492 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.5.3

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UF12
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-15 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
LoVo cell
-
 Homo sapiens
-
RKO cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-4-hydroxy-L-proline + cytochrome c
-
 Homo sapiens (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + reduced cytochrome c
-
 ?

Synonyms

Synonyms Comment Organism
hydroxyproline oxidase
-
 Homo sapiens
OH-POX
-
 Homo sapiens
ProDH2
-
 Homo sapiens
proline dehydrogenase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens adriamycin induces p53-mediated gene expression and markedly increases the catalytic activity of the enzyme up

General Information

General Information Comment Organism
physiological function the enzyme plays a role in growth regulation, reactive oxygen species generation, and activation of the apoptotic cascade Homo sapiens