Literature summary for 1.5.5.1 extracted from

Rodrigues, J.V.; Gomes, C.M.
Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants (2012), Free Radic. Biol. Med., 53, 12-19.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the electron-transferring flavoprotein beta-D128N mutation occurs in a beta-turn located near the AMP binding site, a region that is involved in intersubunit contacts and establishes outer-sphere interactions with the FAD cofactor, namely at the level of the isoalloxazine moiety. Namely ETF b-D128N and ETF b-R191C,would have an impacton reactive oxygen species generation.The ETF variants show about 70% decreased activity in comparison with the wild-type protein, and establish a rationale for their functional defects	Homo sapiens	?	-	?
reduced electron-transferring flavoprotein + ubiquinone	electron transfer via flavin cofactor	Homo sapiens	electron-transferring flavoprotein + ubiquinol	-	r

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Release 2023.1 (January 2023)