Protein Variants | Comment | Organism |
---|---|---|
G362E | mutation occurs in one of two beta-sheets that form the structure of the FAD binding domain likely disrupting the secondary structur. Phenotype of homozygous let-721 mutant is maternal effects lethality. F1 homozygotes have no gross morphological or developmental defects. The maternal effect lethal manifests as the self-fertilized offspring arrest as unhatched embryos. F1 worms are also self semi-sterile, as unmated homozygous mutants produce significantly fewer embryos than wild-type worms | Caenorhabditis elegans |
S61F | affected residue lies within a conserved domain that interacts with the adenine monophosphate moiety of the FAD prosthetic group. Phenotype of homozygous let-721 mutant is maternal effects lethality. F1 homozygotes have no gross morphological or developmental defects. The maternal effect lethal manifests as the self-fertilized offspring arrest as unhatched embryos. F1 worms are also self semi-sterile, as unmated homozygous mutants produce significantly fewer embryos than wild-type worms | Caenorhabditis elegans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | ETFDH is an inner mitochondrial membrane localized enzyme | Caenorhabditis elegans | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gonad | RNA transcribed in somatic gonads | Caenorhabditis elegans | - |
hypodermis | RNA transcribed | Caenorhabditis elegans | - |
intestine | RNA transcribed | Caenorhabditis elegans | - |
muscle | RNA transcribed in body wall muscle | Caenorhabditis elegans | - |
pharynx | RNA transcribed | Caenorhabditis elegans | - |
Synonyms | Comment | Organism |
---|---|---|
electron-transferring flavoprotein dehydrogenase | - |
Caenorhabditis elegans |
ETFDH | - |
Caenorhabditis elegans |
let-721 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | three cis-regulatory sequences (pha-site, rep-site, and act-site) are identified. Phylogenetic footprinting of each site indicates that they are conserved between four Caenorhabditis species. Results show that let-721 is under complex transcriptional control | Caenorhabditis elegans |