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Literature summary for 1.5.3.7 extracted from

  • Zabriskie, T.M.; Liang, X.
    Mechanism-based inactivity of L-pipecolate oxidase by a sulfur-containing substrate analog, 5-thia-L-pipecolic acid (1997), Bioorg. Med. Chem. Lett., 7, 457-462.
No PubMed abstract available
Search for more literature for 1.5.3.7

Inhibitors

Inhibitors Comment Organism Structure
(S)-1,3-thiazane-4-carboxylic acid causes time-dependent, irreversible, stereospecific inactivation Macaca mulatta
L-homocysteine at 0.005 mM 12% inactivation after 1 h incubation Macaca mulatta

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5
-
 L-pipecolic acid
-
 Macaca mulatta

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome membrane-associated Macaca mulatta 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 1 * 46000, SDS-PAGE Macaca mulatta

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-pipecolate + O2 Macaca mulatta
-
 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 the product reacts with water to form 2-aminoadipate 6-semialdehyde ?

Organism

Organism UniProt Comment Textmining
Macaca mulatta
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-1,3-thiazane-4-carboxylic acid + O2
-
 Macaca mulatta ? + H2O2
-
 ?
L-pipecolate + O2
-
 Macaca mulatta 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 the product reacts with water to form 2-aminoadipate 6-semialdehyde ?

Subunits

Subunits Comment Organism
monomer 1 * 46000, SDS-PAGE Macaca mulatta

Cofactor

Cofactor Comment Organism Structure
FAD covalently bound Macaca mulatta

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
36
-
 (S)-1,3-thiazane-4-carboxylic acid competitive inhibitor that completely inactivates the enzyme Macaca mulatta