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Literature summary for 1.5.3.6 extracted from

  • Decker, K.; Dai, V.D.; Möhler, H.; Bruhmuller, M.
    D- and L-6-hydroxynicotine oxidase, enantioenzymes of Arthrobacter oxidans (1972), Z. Naturforsch. B, 27, 1072-1073.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2,6-dichlorophenolindophenol the rate of the overall process is higher than with oxygen Paenarthrobacter nicotinovorans
methylene blue the rate of the overall process is higher than with oxygen Paenarthrobacter nicotinovorans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-6-hydroxynicotine + H2O + O2 Paenarthrobacter nicotinovorans
-
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
?
additional information Paenarthrobacter nicotinovorans enzyme production is induced by growing cells in D,L-nicotine as only source of carbon and nitrogen ?
-
?

Organism

Organism UniProt Comment Textmining
Paenarthrobacter nicotinovorans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-6-hydroxynicotine + H2O + O2
-
Paenarthrobacter nicotinovorans 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
?
(R)-6-hydroxynicotine + H2O + O2
-
Paenarthrobacter nicotinovorans 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2 transcient product is 6-hydroxy-N-methylmyosmine that hydrolyses spontaneously ?
additional information enzyme production is induced by growing cells in D,L-nicotine as only source of carbon and nitrogen Paenarthrobacter nicotinovorans ?
-
?

Subunits

Subunits Comment Organism
monomer
-
Paenarthrobacter nicotinovorans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
19.8
-
6-hydroxy-D-nicotine 30°C pH 9.2 Paenarthrobacter nicotinovorans

Cofactor

Cofactor Comment Organism Structure
FAD one mol FAD per mol enzyme Paenarthrobacter nicotinovorans
FAD covalently bound to a histidine Paenarthrobacter nicotinovorans