Literature summary for 1.5.3.24 extracted from

Chen, Z.W.; Hassan-Abdulah, A.; Zhao, G.; Jorns, M.S.; Mathews, F.S.
Heterotetrameric sarcosine oxidase structure of a diflavin metalloenzyme at 1.85 A resolution (2006), J. Mol. Biol., 360, 1000-1018 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
native protein and the selenomethionine substituted protein, hanging drop vapor diffusion method, using about 17% (w/v) PEG 20000 with 100 mM Tris buffer (pH 8.5)	Stenotrophomonas maltophilia

Inhibitors

Inhibitors	Comment	Organism	Structure
2-furoate	competitive inhibitor with respect to sarcosine	Stenotrophomonas maltophilia

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	contains iron	Stenotrophomonas maltophilia
Zn2+	contains zinc	Stenotrophomonas maltophilia

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
180000	-	gel filtration	Stenotrophomonas maltophilia

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sarcosine + 5,6,7,8-tetrahydrofolate + O2	Stenotrophomonas maltophilia	-	glycine + 5,10-methylenetetrahydrofolate + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Stenotrophomonas maltophilia	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sarcosine + 5,6,7,8-tetrahydrofolate + O2	-	Stenotrophomonas maltophilia	glycine + 5,10-methylenetetrahydrofolate + H2O2	-	?

Subunits

Subunits	Comment	Organism
heterotetramer	1 * 103000 + 1 * 44000 + 1 * 21000 + 1 * 10000, SDS-PAGE	Stenotrophomonas maltophilia

Synonyms

Synonyms	Comment	Organism
heterotetrameric sarcosine oxidase	-	Stenotrophomonas maltophilia
TSOX	-	Stenotrophomonas maltophilia

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Stenotrophomonas maltophilia
FMN	-	Stenotrophomonas maltophilia
NAD+	-	Stenotrophomonas maltophilia

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Release 2023.1 (January 2023)