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Literature summary for 1.5.3.16 extracted from
- Spermine oxidase promotes bile canalicular lumen formation through acrolein production (2017), Sci. Rep., 7, 14841 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | SMOX localizes to the bile canalicular lumen of hepatocytes | Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NWM0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SMOX | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | SMOX plays a role in the formation of bile canalicular lumen in liver cells. Knockdown of SMOX reduces the formation of bile canalicular lumen. Phosphorylated protein kinase B is localized to canalicular lumen and treatment with an inhibitor significantly reduces the formation of bile canalicular lumen. Acrolein scavenger also inhibits the formation of bile canalicular lumen. Tumor suppressor PTEN, phosphatase and tensin homolog and an inhibitor of protein kinase B are alkylated in a SMOX-dependent manner | Homo sapiens |
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