Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6,6'-[ethane-1,2-diyldi(piperidine-4,1-diyl)]bis[N-[(2-methoxyphenyl)methyl]hexan-1-amine] | 17fold selectivity for spermine oxidase over polyamine oxidase | Mus musculus | |
Chlorhexidine | - |
Mus musculus | |
methoctramine | 120fold selectivity for spermine oxidase over polyamine oxidase | Mus musculus | |
N1,N1'-(pentane-1,5-diyl)bis[N6-[(2-methoxyphenyl)methyl]hexane-1,6-diamine] | 9fold selectivity for spermine oxidase over polyamine oxidase | Mus musculus | |
N1,N7-bis(6-[[(2-methoxyphenyl)methyl]amino]hexyl)heptane-1,7-diamine | 40fold selectivity for spermine oxidase over polyamine oxidase | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
N1-[(thiophen-2-yl)methyl]spermine | pH 7.5, 37°C | Mus musculus | |
0.015 | - |
N1-[(naphthalen-2-yl)methyl]spermine | pH 7.5, 37°C | Mus musculus | |
0.019 | - |
N1-benzylspermine | pH 7.5, 37°C | Mus musculus | |
0.245 | - |
N1-[(pyridin-2-yl)methyl]spermine | pH 7.5, 37°C | Mus musculus | |
0.495 | - |
spermine | pH 7.5, 37°C | Mus musculus | |
1.06 | - |
N1-(3-[[(thiophen-2-yl)methyl]amino]propyl)octane-1,8-diamine | pH 7.5, 37°C | Mus musculus | |
1.74 | - |
N1-[(thiophen-2-yl)methyl]dodecane-1,12-diamine | pH 7.5, 37°C | Mus musculus | |
1.99 | - |
N1-benzyldodecane-1,12-diamine | pH 7.5, 37°C | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q99K82 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N1-(3-[[(thiophen-2-yl)methyl]amino]propyl)octane-1,8-diamine + O2 + H2O | - |
Mus musculus | octane-1,8-diamine + N1-[(thiophen-2-yl)methyl]propanal + H2O2 | - |
? | |
N1-benzyldodecane-1,12-diamine + O2 + H2O | - |
Mus musculus | dodecane-1,12-diamine + N1-benzylpropanal + H2O2 | - |
? | |
N1-benzylspermine + O2 + H2O | - |
Mus musculus | spermidine + 3-(benzylamino)propanal + H2O2 | - |
? | |
N1-[(naphthalen-2-yl)methyl]spermine + O2 + H2O | - |
Mus musculus | spermidine + N1-[(naphthalen-2-yl)methyl]propanal + H2O2 | - |
? | |
N1-[(pyridin-2-yl)methyl]spermine + O2 + H2O | - |
Mus musculus | spermidine + N1-[(pyridin-2-yl)methyl]propanal + H2O2 | - |
? | |
N1-[(thiophen-2-yl)methyl]dodecane-1,12-diamine + O2 + H2O | - |
Mus musculus | ? | - |
? | |
N1-[(thiophen-2-yl)methyl]spermine + O2 + H2O | - |
Mus musculus | spermidine + N1-[(thiophen-2-yl)methyl]propanal + H2O2 | - |
? | |
spermine + O2 + H2O | - |
Mus musculus | spermidine + 3-aminopropanal + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMOX | - |
Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
methoctramine | pH 7.5, 37°C | Mus musculus | |
0.0019 | - |
N1,N7-bis(6-[[(2-methoxyphenyl)methyl]amino]hexyl)heptane-1,7-diamine | pH 7.5, 37°C | Mus musculus | |
0.0038 | - |
Chlorhexidine | pH 7.5, 37°C | Mus musculus | |
0.0046 | - |
N1,N1'-(pentane-1,5-diyl)bis[N6-[(2-methoxyphenyl)methyl]hexane-1,6-diamine] | pH 7.5, 37°C | Mus musculus | |
0.0075 | - |
6,6'-[ethane-1,2-diyldi(piperidine-4,1-diyl)]bis[N-[(2-methoxyphenyl)methyl]hexan-1-amine] | pH 7.5, 37°C | Mus musculus |