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Literature summary for 1.5.3.16 extracted from

  • Ceci, R.; Duranti, G.; Leonetti, A.; Pietropaoli, S.; Spinozzi, F.; Marcocci, L.; Amendola, R.; Cecconi, F.; Sabatini, S.; Mariottini, P.; Cervelli, M.
    Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression Evaluation of a new transgenic mouse model (2017), Free Radic. Biol. Med., 103, 216-225 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
spermine + O2 + H2O Mus musculus the enzyme is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. The Total-Smox line is a genetic model useful to deepen the knowledge on the role of spermine oxidase in muscle atrophy and muscular pathological conditions like dystrophy spermidine + 3-aminopropanal + H2O2
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99K82
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
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heart
-
 Mus musculus
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intestine
-
 Mus musculus
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liver
-
 Mus musculus
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lung
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
spermine + O2 + H2O
-
 Mus musculus spermidine + 3-aminopropanal + H2O2
-
 ?
spermine + O2 + H2O the enzyme is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. The Total-Smox line is a genetic model useful to deepen the knowledge on the role of spermine oxidase in muscle atrophy and muscular pathological conditions like dystrophy Mus musculus spermidine + 3-aminopropanal + H2O2
-
 ?

General Information

General Information Comment Organism
physiological function the enzyme is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. The Total-Smox line is a genetic model useful to deepen the knowledge on the role of spermine oxidase in muscle atrophy and muscularpathological conditions like dystrophy Mus musculus