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Literature summary for 1.5.3.16 extracted from

  • Häkkinen, M.; Hyönen, M.; Auriola, S.; Casero Jr., R.; Vepsäläinen, J.; Khomutov, A.; Alhonen, L.; Keinänen, T.
    Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases (2010), Amino Acids, 38, 369-381.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
N1,N4-bis(2,3-butadienyl)-1,4 butanediamine i.e. MDL72527 Homo sapiens
spermidine
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
x * 68000 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SMO is capable of metabolizing several N-alkylated polyamine derivatives, substrate specificity, overview. N1-(3-Ethylaminopropyl)butane-1,4-diamine trihydrochloride is a poor substrate Homo sapiens ?
-
?
N,N'-bis-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O
-
Homo sapiens N-(3-aminopropyl)-N'-(3-benzylaminopropyl)butane-1,4-diamine + N1-(3-benzylaminopropyl)butane-1,4-diamine + H2O2 + ? main products ?
N,N'-bis-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O minor N4-endo cleavage pathways resulting in formation of EtDAP Homo sapiens N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ?
-
?
N-(3-aminopropyl)-N-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O
-
Homo sapiens spermine + H2O2 + ? i.e. N,N'-bis-(3-aminopropyl)butane-1,4-diamine ?
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O
-
Homo sapiens N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ?
-
?
N1-acetylspermine + O2 + H2O the ethyl substituent that retains the amine as positively charged, strongly accelerates the reaction velocity Homo sapiens spermidine + 3-acetamidopropanal + H2O2
-
?

Subunits

Subunits Comment Organism
? x * 68000 Homo sapiens

Synonyms

Synonyms Comment Organism
SMO
-
Homo sapiens

Temperature Optimum [Ā°C]

Temperature Optimum [Ā°C] Temperature Optimum Maximum [Ā°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens no induction of SMO activity by N-alkylated polyamine analogues additional information

General Information

General Information Comment Organism
metabolism SMO is a key enzyme of polyamine catabolism, metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases, overview Homo sapiens