Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N1,N4-bis(2,3-butadienyl)-1,4 butanediamine | i.e. MDL72527 | Homo sapiens | |
spermidine | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
x * 68000 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SMO is capable of metabolizing several N-alkylated polyamine derivatives, substrate specificity, overview. N1-(3-Ethylaminopropyl)butane-1,4-diamine trihydrochloride is a poor substrate | Homo sapiens | ? | - |
? | |
N,N'-bis-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O | - |
Homo sapiens | N-(3-aminopropyl)-N'-(3-benzylaminopropyl)butane-1,4-diamine + N1-(3-benzylaminopropyl)butane-1,4-diamine + H2O2 + ? | main products | ? | |
N,N'-bis-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O | minor N4-endo cleavage pathways resulting in formation of EtDAP | Homo sapiens | N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ? | - |
? | |
N-(3-aminopropyl)-N-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O | - |
Homo sapiens | spermine + H2O2 + ? | i.e. N,N'-bis-(3-aminopropyl)butane-1,4-diamine | ? | |
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O | - |
Homo sapiens | N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ? | - |
? | |
N1-acetylspermine + O2 + H2O | the ethyl substituent that retains the amine as positively charged, strongly accelerates the reaction velocity | Homo sapiens | spermidine + 3-acetamidopropanal + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 68000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
SMO | - |
Homo sapiens |
Temperature Optimum [Ā°C] | Temperature Optimum Maximum [Ā°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | no induction of SMO activity by N-alkylated polyamine analogues | additional information |
General Information | Comment | Organism |
---|---|---|
metabolism | SMO is a key enzyme of polyamine catabolism, metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases, overview | Homo sapiens |