Literature summary for 1.5.3.14 extracted from

Ohkubo, S.; Mancinelli, R.; Miglietta, S.; Cona, A.; Angelini, R.; Canettieri, G.; Spandidos, D.A.; Gaudio, E.; Agostinelli, E.
Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells (2019), Int. J. Oncol., 54, 2080-2094 .

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Application

Application	Comment	Organism
medicine	exogenous spermine and PAO treatment decrease cell viability in a spermine dose- and time-dependent manner, particularly, the viability of the multidrug-resistant colon adenocarcinoma cells, LoVo DX, when compared with drug-sensitive ones. H2O2 derived from spermine is mainly responsible for the cytotoxicity. Treatment with PAO and spermine increases the apoptotic population of LoVo wild-type and multidrug-resistant LoVo cells. Treatment with PAO and spermine markedly reduces mitochondrial membrane potential in the multidrug-resistant LoVo cells	Zea mays

Organism

Organism	UniProt	Comment	Textmining
Zea mays	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)