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Literature summary for 1.5.3.13 extracted from

  • Jaervinen, A.; Keinaenen, T.A.; Grigorenko, N.A.; Khomutov, A.R.; Uimari, A.; Vepsaelaeinen, J.; Naervaenen, A.; Alhonen, L.; Jaenne, J.
    Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase (2006), J. Biol. Chem., 281, 4589-4595.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic characteristics of the degradation of spermidine, racemic, and different isomers of alpha-methylspermidine by human polyamine oxidase in the presence of different aldehydes. Kinetic values of spermine and different diastereomers of bis-alpha,alpha'-methylspermine for human polyamine oxidase in the presence of different aldehydes Homo sapiens
0.0011
-
N1-acetylspermine
-
Homo sapiens
0.0027
-
N1,N11-diacetylnorspermine
-
Homo sapiens
0.014
-
N1-acetylspermidine
-
Homo sapiens
0.047
-
spermine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N1,N12-diacetylspermine + O2 + H2O Homo sapiens
-
?
-
?
N1-acetylspermidine + O2 + H2O Homo sapiens
-
?
-
?
N1-acetylspermine + O2 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-alpha-methylspermidine + O2 + H2O PAO supplemented with benzaldehyde predominantly catalyzes the cleavage of (R)-isomer of alpha-methylspermidine, whereas in the presence of pyridoxal the (S)-alpha-methylspermidine is preferred Homo sapiens ?
-
?
(S)-alpha-methylspermidine + O2 + H2O PAO supplemented with benzaldehyde predominantly catalyzes the cleavage of (R)-isomer of alpha-methylspermidine, whereas in the presence of pyridoxal the (S)-alpha-methylspermidine is preferred Homo sapiens ?
-
?
1-amino-8-acetamido-5-azanonane + O2 + H2O less preferred substrate Homo sapiens ?
-
?
alpha-methylspermine + O2 + H2O
-
Homo sapiens spermidine + alpha-methylspermidine + ?
-
?
bis-alpha,alpha'-methylspermine + O2 + H2O
-
Homo sapiens alpha-methylspermidine + ?
-
?
N1,N11-diacetylnorspermine + O2 + H2O
-
Homo sapiens ?
-
?
N1,N12-diacetylspermine + O2 + H2O
-
Homo sapiens ?
-
?
N1-acetylspermidine + O2 + H2O
-
Homo sapiens ?
-
?
N1-acetylspermine + O2 + H2O
-
Homo sapiens ?
-
?
spermidine + O2 + H2O no activity in absence of aldehydes, weak activity in presence of aldehydes Homo sapiens ?
-
?
spermine + O2 + H2O rather poor substrate for hPAO, aldehyde supplementation greatly increased its degradation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
HPAO
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information kinetic characteristics of the degradation of spermidine, racemic, and different isomers of alpha-methylspermidine by human polyamine oxidase in the presence of different aldehydes. Kinetic values of spermine and different diastereomers of bis-alpha,alpha'-methylspermine for human polyamine oxidase in the presence of different aldehydes Homo sapiens
0.0004
-
spermine
-
Homo sapiens
8.5
-
N1-acetylspermidine
-
Homo sapiens
17
-
N1-acetylspermine
-
Homo sapiens
19
-
N1,N11-diacetylnorspermine
-
Homo sapiens