KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic characteristics of the degradation of spermidine, racemic, and different isomers of alpha-methylspermidine by human polyamine oxidase in the presence of different aldehydes. Kinetic values of spermine and different diastereomers of bis-alpha,alpha'-methylspermine for human polyamine oxidase in the presence of different aldehydes | Homo sapiens | |
0.0011 | - |
N1-acetylspermine | - |
Homo sapiens | |
0.0027 | - |
N1,N11-diacetylnorspermine | - |
Homo sapiens | |
0.014 | - |
N1-acetylspermidine | - |
Homo sapiens | |
0.047 | - |
spermine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N1,N12-diacetylspermine + O2 + H2O | Homo sapiens | - |
? | - |
? | |
N1-acetylspermidine + O2 + H2O | Homo sapiens | - |
? | - |
? | |
N1-acetylspermine + O2 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-alpha-methylspermidine + O2 + H2O | PAO supplemented with benzaldehyde predominantly catalyzes the cleavage of (R)-isomer of alpha-methylspermidine, whereas in the presence of pyridoxal the (S)-alpha-methylspermidine is preferred | Homo sapiens | ? | - |
? | |
(S)-alpha-methylspermidine + O2 + H2O | PAO supplemented with benzaldehyde predominantly catalyzes the cleavage of (R)-isomer of alpha-methylspermidine, whereas in the presence of pyridoxal the (S)-alpha-methylspermidine is preferred | Homo sapiens | ? | - |
? | |
1-amino-8-acetamido-5-azanonane + O2 + H2O | less preferred substrate | Homo sapiens | ? | - |
? | |
alpha-methylspermine + O2 + H2O | - |
Homo sapiens | spermidine + alpha-methylspermidine + ? | - |
? | |
bis-alpha,alpha'-methylspermine + O2 + H2O | - |
Homo sapiens | alpha-methylspermidine + ? | - |
? | |
N1,N11-diacetylnorspermine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
N1,N12-diacetylspermine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
N1-acetylspermidine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
N1-acetylspermine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
spermidine + O2 + H2O | no activity in absence of aldehydes, weak activity in presence of aldehydes | Homo sapiens | ? | - |
? | |
spermine + O2 + H2O | rather poor substrate for hPAO, aldehyde supplementation greatly increased its degradation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HPAO | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic characteristics of the degradation of spermidine, racemic, and different isomers of alpha-methylspermidine by human polyamine oxidase in the presence of different aldehydes. Kinetic values of spermine and different diastereomers of bis-alpha,alpha'-methylspermine for human polyamine oxidase in the presence of different aldehydes | Homo sapiens | |
0.0004 | - |
spermine | - |
Homo sapiens | |
8.5 | - |
N1-acetylspermidine | - |
Homo sapiens | |
17 | - |
N1-acetylspermine | - |
Homo sapiens | |
19 | - |
N1,N11-diacetylnorspermine | - |
Homo sapiens |