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Literature summary for 1.5.1.6 extracted from

  • Oleinik, N.V.; Krupenko, S.A.
    Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis (2003), Mol. Cancer Res., 1, 577-588.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens FDH-expressing cells show accumulation of cells in G0-G1 phase and a sharp decrease of cells in S phase. Accumulation of the tumor suppressor protein p53 and its downstream target p21. FDH antiproliferative effects on A549 cells include both G1 cell cycle arrest and caspase-dependent apoptosis ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell inducible expression of 10-formyltetrahydrofolate dehydrogenase Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + NADP+ + H2O
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Homo sapiens tetrahydrofolate + CO2 + NADPH + H+
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?
additional information FDH-expressing cells show accumulation of cells in G0-G1 phase and a sharp decrease of cells in S phase. Accumulation of the tumor suppressor protein p53 and its downstream target p21. FDH antiproliferative effects on A549 cells include both G1 cell cycle arrest and caspase-dependent apoptosis Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
10-formyltetrahydrofolate dehydrogenase
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Homo sapiens
FDH
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens