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Literature summary for 1.5.1.53 extracted from
- Stereochemistry and mechanism of hydrogen transfer between NADPH and methylenetetrahydrofolate in the reaction catalyzed by methylenetetrahydrofolate reductase from pig liver (1992), J. Am. Chem. Soc., 114, 6949-6956 .
No PubMed abstract available
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NADPH + H+ | - |
Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | Methylenetetrahydrofolate reductase presents reacts with both NADPH and 5,10-methylenetetrahydrofolate at the si face. The reaction involves successive hydride transfers to and from the flavin cofactor. NADP+ dissociates before 5,10-methylenetetrahydrofolate binds the reduced enzyme | Sus scrofa |
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