Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.50 extracted from

  • Bhojane, P.P.; Duff, M.R.; Patel, H.C.; Vogt, M.E.; Howell, E.E.
    Investigation of osmolyte effects on FolM: comparison with other dihydrofolate reductases (2014), Biochemistry, 53, 1330-1341.
    View publication on PubMed

General Stability

General Stability Organism
presence of betaine increases the stability of isoform FolM Escherichia coli

Organic Solvent Stability

Organic Solvent Comment Organism
DMSO both DMSO and ethylene glycol decrease the stability of isoform FolM Escherichia coli
Ethylene glycol both DMSO and ethylene glycol decrease the stability of isoform FolM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AFS3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform FolM possesses weak dihydrofolate reductase activity, EC 1.5.1.3 Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
FolM
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADPH cofactor binding increases in presence of betaine, and weakens in presence of ethylene glycol and polyethylene glycol 400 Escherichia coli