Literature summary for 1.5.1.36 extracted from

Liu, J.; Yin, Y.; Song, Z.; Li, Y.; Jiang, S.; Shao, C.; Wang, Z.
NADH flavin oxidoreductase/NADH oxidase and ROS regulate microsclerotium development in Nomuraea rileyi (2014), World J. Microbiol. Biotechnol., 30, 1927-1935 .

Search for more literature for 1.5.1.36

Cloned(Commentary)

Cloned (Comment)	Organism
gene Nox, DNA and amino acid sequence determination and analysis, phylogenetic tree, quantitative real-time PCR enzyme expresison analysis	Metarhizium rileyi

Protein Variants

Protein Variants	Comment	Organism
additional information	silencing of Nox by RNAi	Metarhizium rileyi

Inhibitors

Inhibitors	Comment	Organism	Structure
H2O2	-	Metarhizium rileyi

Organism

Organism	UniProt	Comment	Textmining
Metarhizium rileyi	A0A059UEY0	-	-
Metarhizium rileyi CQNr01	A0A059UEY0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
microsclerotium	-	Metarhizium rileyi	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
FAD + NADH + H+	-	Metarhizium rileyi	FADH2 + NAD+	-	r
FAD + NADH + H+	-	Metarhizium rileyi CQNr01	FADH2 + NAD+	-	r
FMN + NADH + H+	-	Metarhizium rileyi	FMNH2 + NAD+	-	r
FMN + NADH + H+	-	Metarhizium rileyi CQNr01	FMNH2 + NAD+	-	r

Subunits

Subunits	Comment	Organism
?	x * 44810, sequence calculation	Metarhizium rileyi

Synonyms

Synonyms	Comment	Organism
NADH: flavin oxidoreductase	-	Metarhizium rileyi
NADH: flavinoxidore ductase/NADH oxidase	-	Metarhizium rileyi
NOX	-	Metarhizium rileyi

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Metarhizium rileyi
NADH	-	Metarhizium rileyi

pI Value

Organism	Comment	pI Value Maximum	pI Value
Metarhizium rileyi	sequence calculation	-	7.12

Expression

Organism	Comment	Expression
Metarhizium rileyi	expression level of gene Nox is upregulated and co-related to the intracellular H2O2 concentration during microsclerotium initiation	up

General Information

General Information	Comment	Organism
malfunction	inhibition of Nox causes a noticeable decrease in the microsclerotium yields. Silencing of Nox decreases the microsclerotium yield by 98.5%, H2O2 and virulence decrease it by 38% and 21.5%, respectively	Metarhizium rileyi
physiological function	the enzyme Nox is required for microsclerotium differentiation through regulation of intracellular H2O2 concentration. Additionally Nox has a great impact on the virulence in Nomuraea rileyi in cabbage caterpillar	Metarhizium rileyi

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Release 2023.1 (January 2023)