Literature summary for 1.5.1.34 extracted from

Schormann, N.; Pal, B.; Senkovich, O.; Carson, M.; Howard, A.; Smith, C.; Delucas, L.; Chattopadhyay, D.
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor (2005), J. Struct. Biol., 152, 64-75.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
selenomethionine-substitued enzyme in complex with inhibitor methotrexate or substrate dihydrofolate	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+	catalytic triad consists of Y182, K186, and D169	Trypanosoma cruzi	a

Synonyms

Synonyms	Comment	Organism
PTR2	-	Trypanosoma cruzi

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)