Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.34 extracted from

  • Vasudevan, S.G.; Shaw, D.C.; Armarego, W.L.F.
    Dihydropteridine reductase from Escherichia coli (1988), Biochem. J., 255, 581-588.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
methotrexate competitive vs. quinoid 6-methyl-7,8-dihydropterin Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.091
-
NADH
-
Escherichia coli
0.128
-
quinonoid-6-methyl-7,8-dihydrobiopterin
-
Escherichia coli
0.226
-
quinonoid dihydrobiopterin
-
Escherichia coli
0.29
-
NADPH
-
Escherichia coli
0.525
-
quinonoid-6,7-dimethyl-7,8-dihydropterin
-
Escherichia coli
1.05
-
Quinonoid dihydroneopterin
-
Escherichia coli
1.32
-
Quinonoid dihydromonapterin
-
Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
2 * 27000, SDS-PAGE Escherichia coli
27000
-
2 * 27000 Escherichia coli
54000
-
gel filtration Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
20.7
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6,7-dimethyl-7,8-dihydropteridine + NADPH
-
Escherichia coli (6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
-
?
K3Fe(CN)6 + NAD(P)H
-
Escherichia coli K4Fe(CN)6 + NAD(P)+
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
-
Escherichia coli 6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
-
Escherichia coli 6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H enzyme also has pterin-independent NADH and NADPH oxidoreductase activity with potassium ferricyanide Escherichia coli 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
?
quinonoid dihydrobiopterin + NADH + H+
-
Escherichia coli 6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
?
quinonoid dihydromonapterin + NAD(P)H
-
Escherichia coli tetrahydromonapterin + NAD(P)+
-
?
quinonoid dihydroneopterin + NAD(P)H
-
Escherichia coli tetrahydroneopterin + NAD(P)+
-
?
quinonoid-6-methyl-7,8-dihydrobiopterin + NADH + H+
-
Escherichia coli 6-methyl-7,8-dihydropterin + NAD+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 27000, SDS-PAGE Escherichia coli
dimer 2 * 27000 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
FAD contains bound FAD Escherichia coli
NADH utilizes both NADH and NADPH Escherichia coli
NADPH utilizes both NADH and NADPH Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.26
-
methotrexate
-
Escherichia coli