Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methotrexate | competitive vs. quinoid 6-methyl-7,8-dihydropterin | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.091 | - |
NADH | - |
Escherichia coli | |
0.128 | - |
quinonoid-6-methyl-7,8-dihydrobiopterin | - |
Escherichia coli | |
0.226 | - |
quinonoid dihydrobiopterin | - |
Escherichia coli | |
0.29 | - |
NADPH | - |
Escherichia coli | |
0.525 | - |
quinonoid-6,7-dimethyl-7,8-dihydropterin | - |
Escherichia coli | |
1.05 | - |
Quinonoid dihydroneopterin | - |
Escherichia coli | |
1.32 | - |
Quinonoid dihydromonapterin | - |
Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
2 * 27000, SDS-PAGE | Escherichia coli |
27000 | - |
2 * 27000 | Escherichia coli |
54000 | - |
gel filtration | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
20.7 | - |
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,7-dimethyl-7,8-dihydropteridine + NADPH | - |
Escherichia coli | (6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+ | - |
? | |
K3Fe(CN)6 + NAD(P)H | - |
Escherichia coli | K4Fe(CN)6 + NAD(P)+ | - |
? | |
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H | - |
Escherichia coli | 6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+ | - |
? | |
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H | - |
Escherichia coli | 6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+ | - |
? | |
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | enzyme also has pterin-independent NADH and NADPH oxidoreductase activity with potassium ferricyanide | Escherichia coli | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? | |
quinonoid dihydrobiopterin + NADH + H+ | - |
Escherichia coli | 6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+ | - |
? | |
quinonoid dihydromonapterin + NAD(P)H | - |
Escherichia coli | tetrahydromonapterin + NAD(P)+ | - |
? | |
quinonoid dihydroneopterin + NAD(P)H | - |
Escherichia coli | tetrahydroneopterin + NAD(P)+ | - |
? | |
quinonoid-6-methyl-7,8-dihydrobiopterin + NADH + H+ | - |
Escherichia coli | 6-methyl-7,8-dihydropterin + NAD+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 27000, SDS-PAGE | Escherichia coli |
dimer | 2 * 27000 | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | contains bound FAD | Escherichia coli | |
NADH | utilizes both NADH and NADPH | Escherichia coli | |
NADPH | utilizes both NADH and NADPH | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.26 | - |
methotrexate | - |
Escherichia coli |