Literature summary for 1.5.1.34 extracted from

Armarego, W.L.F.; Waring, P.
Inhibition of human brain dihydropteridine reductase [E.C.1.6.99.10] by the oxidation products of catecholamines, the aminochromes (1983), Biochem. Biophys. Res. Commun., 113, 895-899.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol	no inhibition below 0.2 mM	Homo sapiens
Adrenochrome	-	Homo sapiens
aminochrome	oxidation product of adrenaline, competitive vs. NADH	Homo sapiens
dopamine	no inhibition below 0.2 mM	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0047	-	NADH	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
naphthoquinone affinity chromatography, 5'-AMP-Sepharose	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1180	-	enzyme from brain	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6,7-dihydropteridine + NADH	-	Homo sapiens	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
280	-	NADH	enzyme from brain	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0049	-	Adrenochrome	-	Homo sapiens

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Release 2023.1 (January 2023)