Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aminopterin | - |
Ovis aries | |
methotrexate | - |
Ovis aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
quinonoid dihydrobiopterin | cofactor NADH | Ovis aries | |
0.004 | - |
NADH | reduction of quinonoid dihydrobiopterin | Ovis aries | |
0.0057 | - |
NADH | reduction of quinonoid 2-amino-4-hydroxy-6,7-dimetyldihydropteridine | Ovis aries | |
0.006 | - |
quinonoid 2-amino-4-hydroxy-6,7-dimethyldihydropteridine | cofactor NADPH | Ovis aries | |
0.009 | - |
quinonoid dihydrobiopterin | cofactor NADPH | Ovis aries | |
0.0152 | - |
2-amino-4-hydroxy-6,7-dimethyldihydropteridine | cofactor NADH | Ovis aries | |
0.0709 | - |
NADPH | reduction of quinonoid dihydrobiopterin | Ovis aries | |
0.08 | - |
NADPH | reduction of quinonoid 2-amino-4-hydroxy-6,7-dimethyldihydropteridine | Ovis aries |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
2 * 21000, liver, SDS-PAGE | Ovis aries |
41000 | - |
gradient PAGE | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | Ovis aries | essential component of the hepatic phenylalanine hydroxylating system | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | - |
Ovis aries | - |
brain | - |
Ovis aries | - |
heart | low activity | Ovis aries | - |
kidney | - |
Ovis aries | - |
liver | - |
Ovis aries | - |
skeletal muscle | low activity | Ovis aries | - |
spleen | low activity | Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
15.6 | - |
- |
Ovis aries |
Storage Stability | Organism |
---|---|
-80°C, stable for years | Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H | - |
Ovis aries | 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+ | - |
? | |
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H | - |
Ovis aries | 6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+ | - |
? | |
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | absolutely specific for quinonoid dihydro-isomer corresponding to 7,8-dihydropterins | Ovis aries | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? | |
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | essential component of the hepatic phenylalanine hydroxylating system | Ovis aries | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? | |
quinonoid dihydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)H | approx. one-third of activity with 2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropterid | Ovis aries | tetrahydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)+ | - |
? | |
quinonoid dihydrobiopterin + NADH + H+ | - |
Ovis aries | 6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 21000, liver, SDS-PAGE | Ovis aries |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.8 | 7.8 | pH 6.8: about 45% activity, pH 7.8: about 15% activity | Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | utilizes both NADH and NADPH | Ovis aries | |
NADH | enzyme prefers NADH | Ovis aries | |
NADPH | utilizes both NADH and NADPH | Ovis aries | |
NADPH | NADH is preferred | Ovis aries |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.038 | - |
methotrexate | - |
Ovis aries |