Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
pteridine reductase 1 | - |
Leishmania major |
PTR1 | - |
Leishmania major |
General Information | Comment | Organism |
---|---|---|
malfunction | comparisons of isogenic lines shows that ptr1-null mutants are 18fold more sensitive to H2O2 than PTR1-overproducing lines, and significant 3-5fold differences are seen with a broad panel of oxidant-inducing agents | Leishmania major |
physiological function | using treatment with H2O2 as the selective pressure PTR1 is identified as a mediator of susceptibility to oxidative stress. Oxidant resistance depends upon reduced unconjugated pteridines and PTR1-derived pteridines can modulate oxidant susceptibility | Leishmania major |