Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.33 extracted from

  • Nare, B.; Garraway, L.A.; Vickers, T.J.; Beverley, S.M.
    PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major (2009), Curr. Genet., 55, 287-299.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Synonyms

Synonyms Comment Organism
pteridine reductase 1
-
Leishmania major
PTR1
-
Leishmania major

General Information

General Information Comment Organism
malfunction comparisons of isogenic lines shows that ptr1-null mutants are 18fold more sensitive to H2O2 than PTR1-overproducing lines, and significant 3-5fold differences are seen with a broad panel of oxidant-inducing agents Leishmania major
physiological function using treatment with H2O2 as the selective pressure PTR1 is identified as a mediator of susceptibility to oxidative stress. Oxidant resistance depends upon reduced unconjugated pteridines and PTR1-derived pteridines can modulate oxidant susceptibility Leishmania major