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Literature summary for 1.5.1.31 extracted from
- Formation of (R)-configurated tetrahydroberberine alkaloids in vivo and in vitro (1991), Tetrahedron Lett., 32, 487-490.
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| berberine + NADPH | Corydalis cava | (R)-tetrahydroberberines are formed from protoberberines by a highly stereoselective reduction system | canadine + NADP+ | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corydalis cava | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bulb | - |
Corydalis cava | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,8-dihydroberberine + NADPH | at 64% of the activity with palmatine and NADPH | Corydalis cava | canadine + NADP+ | - |
r | |
| berberine + NADH | at 59% of the activity with palmatine. At 15% of the activity with berberine and NADPH | Corydalis cava | canadine + NAD+ | - |
r | |
| berberine + NADPH | at 59% of the activity with palmatine and NADPH | Corydalis cava | canadine + NADP+ | - |
r | |
| berberine + NADPH | (R)-tetrahydroberberines are formed from protoberberines by a highly stereoselective reduction system | Corydalis cava | canadine + NADP+ | - |
r | |
| columbamine + NADPH | at 39% of the activity with palmatine and NADPH | Corydalis cava | ? + NADP+ | - |
r | |
| coptisine + NADPH | at 47% of the activity with palmatine and NADPH | Corydalis cava | ? + NADP+ | - |
r | |
| dehydroscoulerine + NADPH | at 5% of the activity with palmatine and NADPH | Corydalis cava | ? + NADP+ | - |
r | |
| dihydrosinactine + NADPH | at 52% of the activity with palmatine and NADPH | Corydalis cava | ? + NADP+ | - |
r | |
| jatrorrhizine + NADPH | at 25% of the activity with palmatine and NADPH | Corydalis cava | ? + NADP+ | - |
r | |
| palmatine + NADPH | - |
Corydalis cava | ? + NADP+ | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Corydalis cava |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Corydalis cava |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | at 15% of the activity with NADPH | Corydalis cava | |
| NADP+ | - |
Corydalis cava | |
| NADPH | - |
Corydalis cava | |
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