Literature summary for 1.5.1.3 extracted from

A-Elbasit, I.E.; Alifrangis, M.; Khalil, I.F.; Bygbjerg, I.C.; Masuadi, E.M.; Elbashir, M.I.; Giha, H.A.
The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics (2007), Malar. J., 6, 108.

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Application

Application	Comment	Organism
medicine	in parasites isolated from Sudanese patients treated with sulphadoxine/pyrimethamine or sulphadoxine/pyrimethamine plus chloroquine, mutations have been detected in dihydrofolate reductase at N51I, S108N, and C59R, plus mutations in dihydropteroate synthetase. There is no significant correlation between multiplicity of mutation and response to sulphadoxine/pyrimethamine	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	isolated from Sudanese patients treated with sulphadoxine/pyrimethamine or sulphadoxine/pyrimethamine plus chloroquine	-

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Release 2023.1 (January 2023)