Protein Variants | Comment | Organism |
---|---|---|
additional information | survey of polymorphisms in 35 isolates of Plasmodium malariae collected from five countries in Asia and Africa reveals a low copy number of nonsynonymous mutations in five codons | Plasmodium malariae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Chloroquine | mean 50% inhibitory concentration 74.94 ng/ml in dihydrofolated reductase wild-type from five isolates of Plasmodium malariae collected from five countries in Asia and Africa | Plasmodium malariae | |
pyrimethamine | mean 50% inhibitory concentration 2.24 ng/ml in dihydrofolated reductase wild-type from five isolates of Plasmodium malariae collected from five countries in Asia and Africa | Plasmodium malariae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium malariae | - |
bifunctional dihydrofolate reductase/thymidylate synthase | - |