Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor 1,4-phenylenebis(methylene) bis(N-[amino(imino)methyl](imidothiocarbamate)) and NADPH. Inhibitor exploits a unique binding surface in loop M20 | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2,5-dimethyl-1,4-phenylene)bis(methylene) bis(N-[amino(imino)methyl](imidothiocarbamate)) | 50% inhibition at 0.000075 mM | Escherichia coli | |
1,3-phenylenebis(methylene) bis(N-[amino(imino)methyl](imidothiocarbamate)) | 50% inhibition at 0.000075 mM | Escherichia coli | |
1,4-phenylenebis(methylene) bis(N-[amino(imino)methyl](imidothiocarbamate)) | - |
Escherichia coli | |
2-hydroxy-5-nitrobenzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.0151 mM | Escherichia coli | |
2-methoxybenzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.0033 mM | Escherichia coli | |
3,4-dichlorobenzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.0037 mM | Escherichia coli | |
3,5-bis(trifluoromethyl)benzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.0056 mM | Escherichia coli | |
3-(trifluoromethyl)benzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.0043 mM | Escherichia coli | |
3-methoxybenzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.0038 mM | Escherichia coli | |
4-(trifluoromethyl)benzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.013 mM | Escherichia coli | |
4-methylbenzyl N-[amino(imino)methyl]imidothiocarbamate | 50% inhibition at 0.0126 mM | Escherichia coli | |
methotrexate | 50% inhibition at 0.000003 mM | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0ABQ4 | - |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000115 | - |
1,4-phenylenebis(methylene) bis(N-[amino(imino)methyl](imidothiocarbamate)) | 25°C, pH 7.5 | Escherichia coli |