Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,6-bis-(4-fluoro-phenyl)-[1,3,5]triazine-2,4-diamine | IC50: 0.011 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
3-heptyl-4-hydroxy-1H-naphthalen-2-one | IC50: 0.48 mM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,4-diamine | IC50: 18 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
6,7-dimethyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | IC50: 790 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
6-(4-trifluoromethyl-phenoxy)-quinazoline-2,4-diamine | IC50: 660 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
6-p-tolyloxy-quinazoline-2,4-diamine | IC50: 190 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
6-p-tolylsulfanyl-quinazoline-2,4-diamine | IC50: 310 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
7-methyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | IC50: 0.011 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
N-(4-chloro-2-cyanophenyl)imidodicarbonimidic diamide | IC50: 320 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | |
[amino-(4-[[(amino-thioureido-methyl)-amino]-methyl]-2,5-dimethyl-benzylamino)-methyl]-thiourea | IC50: 109 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH | - |
Escherichia coli | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000000011 | - |
IC50: 0.011 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 7-methyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | |
0.000000011 | - |
IC50: 0.011 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 1,6-bis-(4-fluoro-phenyl)-[1,3,5]triazine-2,4-diamine | |
0.000018 | - |
IC50: 18 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,4-diamine | |
0.000109 | - |
IC50: 109 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | [amino-(4-[[(amino-thioureido-methyl)-amino]-methyl]-2,5-dimethyl-benzylamino)-methyl]-thiourea | |
0.00019 | - |
IC50: 190 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 6-p-tolyloxy-quinazoline-2,4-diamine | |
0.00031 | - |
IC50: 310 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 6-p-tolylsulfanyl-quinazoline-2,4-diamine | |
0.00032 | - |
IC50: 320 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | N-(4-chloro-2-cyanophenyl)imidodicarbonimidic diamide | |
0.00066 | - |
IC50: 660 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 6-(4-trifluoromethyl-phenoxy)-quinazoline-2,4-diamine | |
0.00079 | - |
IC50: 790 nM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 6,7-dimethyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | |
0.48 | - |
IC50: 0.48 mM, 0.03 mM 7,8-dihydrofolate | Escherichia coli | 3-heptyl-4-hydroxy-1H-naphthalen-2-one |