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Literature summary for 1.5.1.3 extracted from

  • Fan, C.C.; Vitols, K.S.; Huennekens, F.M.
    Inhibition of dihydrofolate reductase by methotrexate: a new look at an old problem (1980), Adv. Enzyme Regul., 18, 41-52.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Mus musculus
Bromoacetate
-
Mus musculus
diethyldicarbonate
-
Mus musculus
iodoacetamide under high salt condition Mus musculus
methotrexate biphasic inhibition at pH 7.0, competitive against 7,8-dihydrofolate; dihydrofolate antagonist drug Mus musculus
methylene blue
-
Mus musculus
p-chloromercuribenzoate
-
Mus musculus
Rose bengal
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
multiple forms
-

Source Tissue

Source Tissue Comment Organism Textmining
L-1210 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,8-dihydrofolate + NADPH
-
Mus musculus 5,6,7,8-tetrahydrofolate + NADP+
-
ir
folate + NADPH slow rate Mus musculus 5,6,7,8-tetrahydrofolate + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Mus musculus