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Literature summary for 1.5.1.3 extracted from

  • Blakley, R.L.; McDougall, B.M.
    Dihydrofolic reductase from Streptococcus faecalis R (1961), J. Biol. Chem., 236, 1163-1167.
No PubMed abstract available
Search for more literature for 1.5.1.3

Inhibitors

Inhibitors Comment Organism Structure
aminopterin
-
 Enterococcus faecalis
folate
-
 Enterococcus faecalis
methotrexate i.e. N10-methylpteroylglutamic acid Enterococcus faecalis
p-chloromercuribenzoate
-
 Enterococcus faecalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Enterococcus faecalis
0.004
-
 7,8-dihydrofolate
-
 Enterococcus faecalis

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-
Enterococcus faecalis R / ATCC 8043
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Enterococcus faecalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,8-dihydrofolate + NADPH
-
 Enterococcus faecalis 5,6,7,8-tetrahydrofolate + NADP+
-
 ir
7,8-dihydrofolate + NADPH
-
 Enterococcus faecalis R / ATCC 8043 5,6,7,8-tetrahydrofolate + NADP+
-
 ir

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
-
 Enterococcus faecalis
6.8
-
-
 Enterococcus faecalis

pH Range

pH Minimum pH Maximum Comment Organism
5.3 8 half-maximal activities at pH 5.3 and pH 8.0 Enterococcus faecalis

Cofactor

Cofactor Comment Organism Structure
NADH not Enterococcus faecalis
NADPH
-
 Enterococcus faecalis