General Stability | Organism |
---|---|
stablilized by NADPH, 1 mM | Papaver somniferum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-Coclaurine | - |
Papaver somniferum | |
(S)-N-methylcoclaurine | - |
Papaver somniferum | |
(S)-norreticuline | - |
Papaver somniferum | |
(S)-reticuline | - |
Papaver somniferum | |
6-O-methyllaudanosoline | - |
Papaver somniferum | |
codeine | - |
Papaver somniferum | |
morphine | - |
Papaver somniferum | |
oripavine | - |
Papaver somniferum | |
salutaridine | - |
Papaver somniferum | |
thebaine | - |
Papaver somniferum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
NADPH | - |
Papaver somniferum | |
0.01 | - |
1,2-dehydroreticuline | - |
Papaver somniferum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Papaver somniferum | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
gel filtration | Papaver somniferum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-Dehydroreticuline + NADPH | Papaver somniferum | the enzyme catalyzes the provision of (R)-reticuline for the formation of morphinian alkaloids that possess also (R)-configuration at the chiral centre | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
no activity in Argemone hunnemannii | - |
- |
- |
no activity in Dicentra spectabilis | - |
- |
- |
no activity in Fumaria macrosepta | - |
- |
- |
no activity in Papaver oreophilum | - |
- |
- |
no activity in Papaver persicum | - |
- |
- |
Papaver bracteatum | - |
- |
- |
Papaver somniferum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seedling | - |
Papaver somniferum | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Papaver somniferum |
Storage Stability | Organism |
---|---|
-20°C, 1 mM NADPH, 50% loss of activity after 30 days | Papaver bracteatum |
4°C, 1 mM NADPH, 50% loss of activity after 20 days | Papaver somniferum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-Dehydroreticuline + NADPH | the enzyme catalyzes the provision of (R)-reticuline for the formation of morphinian alkaloids that possess also (R)-configuration at the chiral centre | Papaver somniferum | ? | - |
? | |
1,2-dehydroreticuline + NADPH + H+ | - |
Papaver somniferum | (R)-reticuline + NADP+ | - |
? | |
1,2-dehydroreticuline + NADPH + H+ | - |
Papaver bracteatum | (R)-reticuline + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 30000, SDS-PAGE | Papaver somniferum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Papaver somniferum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Papaver somniferum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Papaver somniferum |