Literature summary for 1.5.1.20 extracted from

Fisher, M.C.; Cronstein, B.N.
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity (2009), J. Rheumatol., 36, 539-545.

Search for more literature for 1.5.1.20

Application

Application	Comment	Organism
medicine	meta-analysis of Mthfr polymorphisms affecting methotrexate toxicity. Polymorphism C677T is associated with increased toxicity of methotrexate,while polymorphism A1298C is not	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A1298C	natural polymorphism. Mutation is not associated with increased toxicity of methotrexate	Homo sapiens
C677T	natural polymorphism. Mutation is associated with increased toxicity of methotrexate	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with rheumatoid arthritis	-

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Release 2023.1 (January 2023)