Application | Comment | Organism |
---|---|---|
medicine | meta-analysis of Mthfr polymorphisms affecting methotrexate toxicity. Polymorphism C677T is associated with increased toxicity of methotrexate,while polymorphism A1298C is not | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A1298C | natural polymorphism. Mutation is not associated with increased toxicity of methotrexate | Homo sapiens |
C677T | natural polymorphism. Mutation is associated with increased toxicity of methotrexate | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with rheumatoid arthritis | - |