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BRENDA support

Literature summary for 1.5.1.20 extracted from

  • Agarwal, R.P.; Peters, S.M.; Shemirani, M.; von Ahsen, N.
    Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design (2007), J. Mol. Diagn., 9, 345-350.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information the disorders of folate metabolism caused by MTHFR gene polymorphisms C677T and A1298C may lead to several disease states including coronary heart disease, venous thrombosis, and several types of cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P42898
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + reduced acceptor
-
Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
?

Synonyms

Synonyms Comment Organism
methylenetetrahydrofolate reductase
-
Homo sapiens
MTHFR
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Homo sapiens