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Literature summary for 1.5.1.20 extracted from

  • Pande, M.; Chen, J.; Amos, C.I.; Lynch, P.M.; Broaddus, R.; Frazier, M.L.
    Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population (2007), Cancer Epidemiol. Biomarkers Prev., 16, 1753-1759.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information the C677T polymorphism modifies the age at onset of colorectal cancer in Caucasian Lynch syndrome subjects with the 677T allele having a protective effect, while there is no association between the MTHFR A1298C polymorphism and age at onset of colorectal cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + reduced acceptor
-
Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
ir

Synonyms

Synonyms Comment Organism
methylenetetrahydrofolate reductase
-
Homo sapiens
MTHFR
-
Homo sapiens