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Literature summary for 1.5.1.20 extracted from
- Two non-complementing genes encoding enzymatically active methylenetertrahydrofolate reductases control methionine requirement in fission yeast Schizosaccharomyces pombe (2002), Yeast, 19, 841-848.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| enzyme is encoded by the 2 genes met9 and met11, which can complement the double-mutant strain, but they cannot complement for each other in the met9-deficient and met11-mutant, respectively, DNA and amino acid sequence determination and analysis | Schizosaccharomyces pombe |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 69000 | - |
x * 69000, met9, SDS-PAGE, x *72100, met11, SDS-PAGE | Schizosaccharomyces pombe |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-methyltetrahydrofolate + NADP+ | Schizosaccharomyces pombe | - |
5,10-methylenetetrahydrofolate + NADPH | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | - |
genes met9 and met11 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-methyltetrahydrofolate + NADP+ | - |
Schizosaccharomyces pombe | 5,10-methylenetetrahydrofolate + NADPH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 69000, met9, SDS-PAGE, x *72100, met11, SDS-PAGE | Schizosaccharomyces pombe |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methylenetetrahydrofolate reductase | - |
Schizosaccharomyces pombe |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Schizosaccharomyces pombe |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.7 | - |
assay at | Schizosaccharomyces pombe |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Schizosaccharomyces pombe | |
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Release 2023.1 (January 2023)
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