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Literature summary for 1.5.1.20 extracted from
- Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae (1999), J. Biol. Chem., 274, 32613-32618.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| wild type and several mutants | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A1298C | high level of enzyme activity, retains 40% of its activity after 20 min at 55°C | Homo sapiens |
| C1141T | high level of enzyme activity, retains 40% of its activity after 20 min at 55°C | Homo sapiens |
| C667T | high level of enzyme activity, loses almost all its activity after 20 min at 55°C, enzyme in patients with TT or TC genotype are more thermolabile than wild type enzyme at 46°C | Homo sapiens |
| G164C | reduced enzyme activity | Homo sapiens |
| G458T | reduced enzyme activity | Homo sapiens |
| T980C | reduced enzyme activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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Release 2023.1 (January 2023)
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