Literature summary for 1.5.1.2 extracted from

Deutch, C.E.; Klarstrom, J.L.; Link, C.L.; Ricciardi, D.L.
Oxidation of L-thiazolidine-4-carboxylate by DELTA1-pyrroline-5-carboxylate reductase in Escherichia coli (2001), Curr. Microbiol., 42, 442-446.

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Inhibitors

Inhibitors	Comment	Organism	Structure
thiazolidine-4-carboxylic acid	42% inhibition at 10 mM, L-isomer	Escherichia coli

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.03	-	NADPH	-	Escherichia coli
0.23	-	NADH	-	Escherichia coli
0.34	-	DL-pyrroline-5-carboxylate	-	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	K-12	-

Purification (Commentary)

Purification (Comment)	Organism
copurification with thiazolidine-4-carboxylate dehydrogenase	Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
15.9	-	-	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-pyrroline-5-carboxylate + NADH + H+	-	Escherichia coli	L-proline + NAD+	-	r
3,4-dehydro-DL-proline + NADPH	-	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)