Protein Variants | Comment | Organism |
---|---|---|
C677T | one of several polymorphisms, leads to increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis, determination of genotypes in liver transplant patients with cirrhosis with and without hepatocellular carcinoma and in healthy persons | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | key enzyme in folate metabolism playing a major role in provision of methyl groups for DNA methylation and in production of dTMP for DNA synthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with alcoholic cirrhosis | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocarcinoma cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | key enzyme in folate metabolism playing a major role in provision of methyl groups for DNA methylation and in production of dTMP for DNA synthesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methylenetetrahydrofolate reductase | - |
Homo sapiens |
More | cf. EC 1.5.1.20 | Homo sapiens |
MTHFR | - |
Homo sapiens |