Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphate | - |
Mus musculus | |
phosphate | absolute requirement, phosphate can be replaced by its analog arsenate | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
recombinant enzyme, expressed in Escherichia coli | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0046 | - |
L-5,10-methylenetetrahydrofolate | - |
Homo sapiens | |
0.18 | - |
Mg2+ | - |
Homo sapiens | |
2.5 | - |
NAD+ | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | absolute requirement | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-5,10-methenyl-tetrahydrofolate + NADH | Mus musculus | - |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
L-5,10-methenyl-tetrahydrofolate + NADH | Homo sapiens | - |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
L-5,10-methenyl-tetrahydrofolate + NADH | Saccharomyces cerevisiae | - |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
L-5,10-methylenetetrahydrofolate + NAD+ | Mus musculus | - |
5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
L-5,10-methylenetetrahydrofolate + NAD+ | Homo sapiens | - |
5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
L-5,10-methylenetetrahydrofolate + NAD+ | Saccharomyces cerevisiae | - |
5,10-methenyl-tetrahydrofolate + NADH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse, Ehrlich ascites tumor cells | - |
Saccharomyces cerevisiae | - |
yeast | - |
Purification (Comment) | Organism |
---|---|
from ascites tumor cells | Mus musculus |
recombinant enzyme, expressed in Escherichia coli | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
fetus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-5,10-methenyl-tetrahydrofolate + NADH | - |
Mus musculus | L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
L-5,10-methenyl-tetrahydrofolate + NADH | - |
Homo sapiens | L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
L-5,10-methenyl-tetrahydrofolate + NADH | - |
Saccharomyces cerevisiae | L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
Mus musculus | 5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
Homo sapiens | 5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
Saccharomyces cerevisiae | 5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
additional information | - |
Mus musculus | ? | - |
? | |
additional information | - |
Saccharomyces cerevisiae | ? | - |
? | |
additional information | bifunctional enzyme | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Mg2+-/phosphate-dependent dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NAD+ | - |
Saccharomyces cerevisiae | |
NAD+ | NAD+ cofactor can be replaced by NADP+ | Homo sapiens |