BRENDA - Enzyme Database
show all sequences of 1.5.1.1

Enzymatic synthesis of L-pipecolic acid and L-proline

Meister, A.; Radhakrishnan, A.N.; Buckley, S.D.; J. Biol. Chem. 229, 789-800 (1957)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.038
-
NADPH
+ DELTA1-pyrroline-2-carboxylate
Rattus norvegicus
0.043
-
NADH
+ DELTA1-pyrroline-2-carboxylate
Rattus norvegicus
0.06
-
DELTA1-piperidine-2-carboxylate
cosubstrate NADH
Rattus norvegicus
0.074
-
NADH
+ DELTA1-piperidine-2-carboxylate
Rattus norvegicus
0.082
-
DELTA1-pyrroline-2-carboxylate
cosubstrate NADH
Rattus norvegicus
0.12
-
DELTA1-pyrroline-2-carboxylate
cosubstrate NADPH
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
Vigna radiata var. radiata
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Rattus norvegicus
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Neurospora crassa
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Pisum sativum
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Klebsiella aerogenes
-
L-pipecolic acid + NAD(P)+
-
-
-
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Vigna radiata var. radiata
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Rattus norvegicus
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Neurospora crassa
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Pisum sativum
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Klebsiella aerogenes
-
L-proline + NAD(P)+
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Klebsiella aerogenes
-
-
-
Neurospora crassa
-
-
-
Pisum sativum
-
-
-
Rattus norvegicus
-
-
-
Vigna radiata var. radiata
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
-
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
seed
germinated seed
Pisum sativum
-
seed
germinated seed
Vigna radiata var. radiata
-
skeletal muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
specific activities in homogenates of various organs
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-pipecolic acid + NAD(P)+
-
392038
Vigna radiata var. radiata
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-pipecolic acid + NAD(P)+
-
392038
Rattus norvegicus
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-pipecolic acid + NAD(P)+
-
392038
Neurospora crassa
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-pipecolic acid + NAD(P)+
-
392038
Pisum sativum
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Klebsiella aerogenes
L-pipecolic acid + NAD(P)+
-
-
-
-
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-proline + NAD(P)+
-
392038
Vigna radiata var. radiata
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-proline + NAD(P)+
-
392038
Rattus norvegicus
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-proline + NAD(P)+
-
392038
Neurospora crassa
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-proline + NAD(P)+
-
392038
Pisum sativum
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Klebsiella aerogenes
L-proline + NAD(P)+
-
-
-
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
-
DELTA1-piperidine-2-carboxylate
Rattus norvegicus
6.8
-
DELTA1-pyrroline-2-carboxylate
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Rattus norvegicus
NADH
-
Klebsiella aerogenes
NADH
-
Neurospora crassa
NADH
-
Pisum sativum
NADH
-
Vigna radiata var. radiata
NADPH
-
Rattus norvegicus
NADPH
-
Klebsiella aerogenes
NADPH
-
Neurospora crassa
NADPH
-
Pisum sativum
NADPH
-
Vigna radiata var. radiata
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Rattus norvegicus
NADH
-
Klebsiella aerogenes
NADH
-
Neurospora crassa
NADH
-
Pisum sativum
NADH
-
Vigna radiata var. radiata
NADPH
-
Rattus norvegicus
NADPH
-
Klebsiella aerogenes
NADPH
-
Neurospora crassa
NADPH
-
Pisum sativum
NADPH
-
Vigna radiata var. radiata
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.038
-
NADPH
+ DELTA1-pyrroline-2-carboxylate
Rattus norvegicus
0.043
-
NADH
+ DELTA1-pyrroline-2-carboxylate
Rattus norvegicus
0.06
-
DELTA1-piperidine-2-carboxylate
cosubstrate NADH
Rattus norvegicus
0.074
-
NADH
+ DELTA1-piperidine-2-carboxylate
Rattus norvegicus
0.082
-
DELTA1-pyrroline-2-carboxylate
cosubstrate NADH
Rattus norvegicus
0.12
-
DELTA1-pyrroline-2-carboxylate
cosubstrate NADPH
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
Vigna radiata var. radiata
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Rattus norvegicus
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Neurospora crassa
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Pisum sativum
-
L-pipecolic acid + NAD(P)+
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
Klebsiella aerogenes
-
L-pipecolic acid + NAD(P)+
-
-
-
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Vigna radiata var. radiata
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Rattus norvegicus
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Neurospora crassa
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Pisum sativum
-
L-proline + NAD(P)+
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Klebsiella aerogenes
-
L-proline + NAD(P)+
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
seed
germinated seed
Pisum sativum
-
seed
germinated seed
Vigna radiata var. radiata
-
skeletal muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
specific activities in homogenates of various organs
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-pipecolic acid + NAD(P)+
-
392038
Vigna radiata var. radiata
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-pipecolic acid + NAD(P)+
-
392038
Rattus norvegicus
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-pipecolic acid + NAD(P)+
-
392038
Neurospora crassa
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-pipecolic acid + NAD(P)+
-
392038
Pisum sativum
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392038
Klebsiella aerogenes
L-pipecolic acid + NAD(P)+
-
-
-
-
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Vigna radiata var. radiata
L-proline + NAD(P)+
-
392038
Vigna radiata var. radiata
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Rattus norvegicus
L-proline + NAD(P)+
-
392038
Rattus norvegicus
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Neurospora crassa
L-proline + NAD(P)+
-
392038
Neurospora crassa
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Pisum sativum
L-proline + NAD(P)+
-
392038
Pisum sativum
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392038
Klebsiella aerogenes
L-proline + NAD(P)+
-
-
-
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
-
DELTA1-piperidine-2-carboxylate
Rattus norvegicus
6.8
-
DELTA1-pyrroline-2-carboxylate
Rattus norvegicus
Other publictions for EC 1.5.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742531
Watanabe
Identification and characteri ...
Azospirillum brasilense, Colwellia psychrerythraea
FEBS Open Bio
4
240-250
2014
-
-
1
-
1
-
-
24
-
-
7
3
-
5
-
-
-
-
-
1
22
-
28
3
9
1
-
-
25
2
-
-
3
-
-
-
-
-
1
3
-
1
-
-
-
-
24
-
-
7
3
-
-
-
-
-
1
22
-
28
3
1
-
-
25
2
-
-
-
1
4
4
1
25
25
743353
Hallen
-
Imine reductases A comparison ...
Rattus norvegicus
Neurochem. Res.
39
527-541
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
741580
Hallen
Lysine metabolism in mammalia ...
Rattus norvegicus, Sus scrofa
Amino Acids
45
1249-1272
2013
-
-
-
-
-
-
-
-
4
-
-
4
-
2
-
-
2
-
-
7
-
-
5
-
6
-
-
-
-
-
-
-
6
-
-
-
-
-
-
6
-
-
-
-
-
-
-
4
-
-
4
-
-
-
2
-
7
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656290
Muramatsu
The putative malate/lactate de ...
Pseudomonas putida
J. Biol. Chem.
280
5329-5335
2005
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
6
-
6
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
4
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
6
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674509
Goto
Crystal structures of DELTA1-p ...
Pseudomonas syringae
J. Biol. Chem.
280
40875-40884
2005
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392037
Garweg
L-Pipecolate formation in the ...
Canis lupus familiaris, Cercocebus sp., Mus musculus
J. Neurochem.
35
616-621
1980
-
-
-
-
-
-
2
4
-
-
-
6
-
6
-
-
-
-
-
6
3
-
12
-
-
3
-
-
-
2
-
-
3
1
-
-
-
-
-
3
-
-
-
-
2
1
4
-
-
-
6
-
-
-
-
-
6
3
-
12
-
3
-
-
-
2
-
-
-
-
-
-
-
-
-
392038
Meister
Enzymatic synthesis of L-pipec ...
Klebsiella aerogenes, Neurospora crassa, Pisum sativum, Rattus norvegicus, Vigna radiata var. radiata
J. Biol. Chem.
229
789-800
1957
-
-
-
-
-
-
-
6
-
-
-
10
-
5
-
-
1
-
-
9
1
-
18
-
-
-
-
-
-
2
-
-
10
-
-
-
-
-
-
10
-
-
-
-
-
-
6
-
-
-
10
-
-
-
1
-
9
1
-
18
-
-
-
-
-
2
-
-
-
-
-
-
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