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Literature summary for 1.5.1.1 extracted from

  • Garweg, G.; von Rehren, D.; Hintze, U.
    L-Pipecolate formation in the mammalian brain. Regional distribution of DELTA1-pyrroline-2-carboxylate reductase activity (1980), J. Neurochem., 35, 616-621.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information not: p-hydroxymercuribenzoate Mus musculus
N-formyl-L-methionine non competitive inhibition, EDTA decreases the inhibition rate Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
NADH + DELTA1-piperidine-2-carboxylate Mus musculus
0.21
-
DELTA1-piperidine-2-carboxylate
-
Mus musculus
0.43
-
NADH + DELTA1-pyrroline-2-carboxylate Mus musculus
0.86
-
DELTA1-pyrroline-2-carboxylate
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DELTA1-piperidine-2-carboxylate + NAD(P)H Mus musculus
-
L-pipecolic acid + NAD(P)+
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H Canis lupus familiaris
-
L-pipecolic acid + NAD(P)+
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H Cercocebus sp.
-
L-pipecolic acid + NAD(P)+
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H Mus musculus
-
L-proline + NAD(P)+
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H Canis lupus familiaris
-
L-proline + NAD(P)+
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H Cercocebus sp.
-
L-proline + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
beagle
-
Cercocebus sp.
-
monkey
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain prosencephalic region Mus musculus
-
brain prosencephalic region Canis lupus familiaris
-
brain prosencephalic region Cercocebus sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [┬Ámol/min/mg] Specific Activity Maximum [┬Ámol/min/mg] Comment Organism
additional information
-
specific activities in various brain regions Mus musculus
additional information
-
specific activities in various brain regions Canis lupus familiaris
additional information
-
specific activities in various brain regions Cercocebus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-pyrroline-2-carboxylate + NADH + H+
-
Mus musculus L-proline + NAD+
-
r
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
Mus musculus L-pipecolic acid + NAD(P)+
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
Canis lupus familiaris L-pipecolic acid + NAD(P)+
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
Cercocebus sp. L-pipecolic acid + NAD(P)+
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
Mus musculus L-proline + NAD(P)+
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
Canis lupus familiaris L-proline + NAD(P)+
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
Cercocebus sp. L-proline + NAD(P)+
-
?

Temperature Optimum [┬░C]

Temperature Optimum [┬░C] Temperature Optimum Maximum [┬░C] Comment Organism
30
-
assay at Mus musculus
30
-
assay at Canis lupus familiaris
30
-
assay at Cercocebus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.2
-
DELTA1-pyrroline-2-carboxylate Mus musculus
5.4
-
DELTA1-piperidine-2-carboxylate Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Mus musculus
NADH
-
Canis lupus familiaris
NADH
-
Cercocebus sp.

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.18
-
N-formyl-L-methionine
-
Mus musculus