BRENDA - Enzyme Database
show all sequences of 1.5.1.1

L-Pipecolate formation in the mammalian brain. Regional distribution of DELTA1-pyrroline-2-carboxylate reductase activity

Garweg, G.; von Rehren, D.; Hintze, U.; J. Neurochem. 35, 616-621 (1980)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
not: p-hydroxymercuribenzoate
Mus musculus
N-formyl-L-methionine
non competitive inhibition, EDTA decreases the inhibition rate
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.02
-
NADH
+ DELTA1-piperidine-2-carboxylate
Mus musculus
0.21
-
DELTA1-piperidine-2-carboxylate
-
Mus musculus
0.43
-
NADH
+ DELTA1-pyrroline-2-carboxylate
Mus musculus
0.86
-
DELTA1-pyrroline-2-carboxylate
-
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
Mus musculus
-
L-pipecolic acid + NAD(P)+
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-pipecolic acid + NAD(P)+
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-pipecolic acid + NAD(P)+
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Mus musculus
-
L-proline + NAD(P)+
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-proline + NAD(P)+
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-proline + NAD(P)+
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Canis lupus familiaris
-
beagle
-
Cercocebus sp.
-
monkey
-
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
prosencephalic region
Canis lupus familiaris
-
brain
prosencephalic region
Cercocebus sp.
-
brain
prosencephalic region
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
specific activities in various brain regions
Canis lupus familiaris
additional information
-
specific activities in various brain regions
Cercocebus sp.
additional information
-
specific activities in various brain regions
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
392037
Mus musculus
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
392037
Canis lupus familiaris
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
392037
Cercocebus sp.
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
392037
Mus musculus
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
392037
Canis lupus familiaris
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
392037
Cercocebus sp.
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Canis lupus familiaris
30
-
assay at
Cercocebus sp.
30
-
assay at
Mus musculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.2
-
DELTA1-pyrroline-2-carboxylate
Mus musculus
5.4
-
DELTA1-piperidine-2-carboxylate
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Canis lupus familiaris
NADH
-
Cercocebus sp.
NADH
-
Mus musculus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.18
-
N-formyl-L-methionine
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Canis lupus familiaris
NADH
-
Cercocebus sp.
NADH
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
not: p-hydroxymercuribenzoate
Mus musculus
N-formyl-L-methionine
non competitive inhibition, EDTA decreases the inhibition rate
Mus musculus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.18
-
N-formyl-L-methionine
-
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.02
-
NADH
+ DELTA1-piperidine-2-carboxylate
Mus musculus
0.21
-
DELTA1-piperidine-2-carboxylate
-
Mus musculus
0.43
-
NADH
+ DELTA1-pyrroline-2-carboxylate
Mus musculus
0.86
-
DELTA1-pyrroline-2-carboxylate
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
Mus musculus
-
L-pipecolic acid + NAD(P)+
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-pipecolic acid + NAD(P)+
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-pipecolic acid + NAD(P)+
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Mus musculus
-
L-proline + NAD(P)+
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-proline + NAD(P)+
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-proline + NAD(P)+
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
prosencephalic region
Canis lupus familiaris
-
brain
prosencephalic region
Cercocebus sp.
-
brain
prosencephalic region
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
specific activities in various brain regions
Canis lupus familiaris
additional information
-
specific activities in various brain regions
Cercocebus sp.
additional information
-
specific activities in various brain regions
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
392037
Mus musculus
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
392037
Canis lupus familiaris
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
392037
Cercocebus sp.
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
392037
Mus musculus
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
392037
Canis lupus familiaris
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
392037
Cercocebus sp.
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Canis lupus familiaris
30
-
assay at
Cercocebus sp.
30
-
assay at
Mus musculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.2
-
DELTA1-pyrroline-2-carboxylate
Mus musculus
5.4
-
DELTA1-piperidine-2-carboxylate
Mus musculus
Other publictions for EC 1.5.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742531
Watanabe
Identification and characteri ...
Azospirillum brasilense, Colwellia psychrerythraea
FEBS Open Bio
4
240-250
2014
-
-
1
-
1
-
-
24
-
-
7
3
-
5
-
-
-
-
-
1
22
-
28
3
9
1
-
-
25
2
-
-
3
-
-
-
-
-
1
3
-
1
-
-
-
-
24
-
-
7
3
-
-
-
-
-
1
22
-
28
3
1
-
-
25
2
-
-
-
1
4
4
1
25
25
743353
Hallen
-
Imine reductases A comparison ...
Rattus norvegicus
Neurochem. Res.
39
527-541
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
741580
Hallen
Lysine metabolism in mammalia ...
Rattus norvegicus, Sus scrofa
Amino Acids
45
1249-1272
2013
-
-
-
-
-
-
-
-
4
-
-
4
-
2
-
-
2
-
-
7
-
-
5
-
6
-
-
-
-
-
-
-
6
-
-
-
-
-
-
6
-
-
-
-
-
-
-
4
-
-
4
-
-
-
2
-
7
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656290
Muramatsu
The putative malate/lactate de ...
Pseudomonas putida
J. Biol. Chem.
280
5329-5335
2005
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
6
-
6
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
4
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
6
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674509
Goto
Crystal structures of DELTA1-p ...
Pseudomonas syringae
J. Biol. Chem.
280
40875-40884
2005
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392037
Garweg
L-Pipecolate formation in the ...
Canis lupus familiaris, Cercocebus sp., Mus musculus
J. Neurochem.
35
616-621
1980
-
-
-
-
-
-
2
4
-
-
-
6
-
6
-
-
-
-
-
6
3
-
12
-
-
3
-
-
-
2
-
-
3
1
-
-
-
-
-
3
-
-
-
-
2
1
4
-
-
-
6
-
-
-
-
-
6
3
-
12
-
3
-
-
-
2
-
-
-
-
-
-
-
-
-
392038
Meister
Enzymatic synthesis of L-pipec ...
Klebsiella aerogenes, Neurospora crassa, Pisum sativum, Rattus norvegicus, Vigna radiata var. radiata
J. Biol. Chem.
229
789-800
1957
-
-
-
-
-
-
-
6
-
-
-
10
-
5
-
-
1
-
-
9
1
-
18
-
-
-
-
-
-
2
-
-
10
-
-
-
-
-
-
10
-
-
-
-
-
-
6
-
-
-
10
-
-
-
1
-
9
1
-
18
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-