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Literature summary for 1.5.1.1 extracted from

  • Hallen, A.; Jamie, J.; Cooper, A.
    Imine reductases A comparison of glutamate dehydrogenase to ketimine reductases in the brain (2014), Neurochem. Res., 39, 527-541 .
No PubMed abstract available
Search for more literature for 1.5.1.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DELTA1-piperideine 2-carboxylate + NADPH + H+ Rattus norvegicus
-
 L-pipecolate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
 Rattus norvegicus L-pipecolate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
P2C/Pyr2C reductase
-
 Rattus norvegicus
P2C/Pyr2C/ketimine reductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzymatic reduction of Pyr2C to L-proline together with DAAO may be regarded as a salvage mechanism for converting D-proline, arising from the diet or intestinal bacteria, to L-proline, the more biological useful enantiomer in mammals Rattus norvegicus