Literature summary for 1.4.3.5 extracted from

Ren, W.; Guan, W.; Zhang, J.; Wang, F.; Xu, G.
Pyridoxine 5-phosphate oxidase is correlated with human breast invasive ductal carcinoma development (2019), Aging, 11, 2151-2176 .

Search for more literature for 1.4.3.5

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NVS9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyridoxine 5'-phosphate + O2	-	Homo sapiens	pyridoxal 5'-phosphate + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
PNPO	-	Homo sapiens
pyridoxine 5'-phosphate oxidase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme (PNPO) is down-regulated and up-regulated by miR-216b-5p mimics and inhibitors, respectively, in breast cancer cells. Knockdown of MALAT1 results in an increase of miR-216b-5p and a decrease of PNPO mRNA, indicating a regulatory mechanism of competing endogenous RNAs	down
Homo sapiens	the enzyme (PNPO) is down-regulated and up-regulated by miR-216b-5p mimics and inhibitors, respectively, in breast cancer cells	up
Homo sapiens	the enzyme is upregulated in patients with invasive ductal carcinoma (IDC) at mRNA and protein levels	up

General Information

General Information	Comment	Organism
metabolism	the enzyme (PNPO) is upregulated in patients with invasive ductal carcinoma (IDC) and is correlated with the overall survival of patients with metastasis at the later stages	Homo sapiens

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Release 2023.1 (January 2023)