Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Clorgyline | irreversible inhibitor of isoform MAO-A | Homo sapiens | |
Clorgyline | irreversible inhibitor of isoform MAO-A | Rattus norvegicus | |
moclobemide | reversible inhibitor of isoform MAO-A | Homo sapiens | |
moclobemide | reversible inhibitor of isoform MAO-A | Rattus norvegicus | |
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide | NTZ-1441; NTZ-1441 | Homo sapiens | |
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide | NTZ-1441; NTZ-1441 | Rattus norvegicus | |
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide | - |
Homo sapiens | |
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide | - |
Rattus norvegicus | |
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide | NTZ-1442; NTZ-1442 | Homo sapiens | |
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide | NTZ-1442; NTZ-1442 | Rattus norvegicus | |
N-phenyl-1H-indazole-5-carboxamide | - |
Homo sapiens | |
N-phenyl-1H-indazole-5-carboxamide | - |
Rattus norvegicus | |
rasagiline | irreversible inhibitor of isoform MAO-B | Homo sapiens | |
rasagiline | irreversible inhibitor of isoform MAO-B | Rattus norvegicus | |
safinamide | reversible inhibitor of isoform MAO-B | Homo sapiens | |
safinamide | reversible inhibitor of isoform MAO-B | Rattus norvegicus | |
selegiline | irreversible inhibitor of isoform MAO-B | Homo sapiens | |
selegiline | irreversible inhibitor of isoform MAO-B | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21397 | - |
- |
Homo sapiens | P27338 | - |
- |
Rattus norvegicus | P19643 | - |
- |
Rattus norvegicus | P21396 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-tyramine + H2O + O2 | - |
Homo sapiens | 2-(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
4-tyramine + H2O + O2 | - |
Rattus norvegicus | 2-(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Homo sapiens |
MAO-B | - |
Rattus norvegicus |
monoamine oxidase A | - |
Homo sapiens |
monoamine oxidase A | - |
Rattus norvegicus |
monoamine oxidase B | - |
Homo sapiens |
monoamine oxidase B | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000000386 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.000000586 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide | |
0.000000679 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide | |
0.00000108 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide | |
0.00000132 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.00000143 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide | |
0.00000144 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.00000152 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.00000159 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide | |
0.00000236 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide | |
0.00000382 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide | |
0.00000565 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.00000889 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide | |
0.0000225 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.0000384 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.000117 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-phenyl-1H-indazole-5-carboxamide | |
0.000221 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.00042 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.000662 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.000708 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-phenyl-1H-indazole-5-carboxamide | |
0.00136 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.00174 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.00188 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.00287 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide | |
0.00518 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | safinamide | |
0.00764 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.00808 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-phenyl-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-phenyl-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
0.01 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide | |
0.018 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | safinamide | |
0.361 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | moclobemide | |
0.708 | - |
isoform MAO-B, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
1.69 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
10 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
10 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide | |
10 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide | |
10.7 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | moclobemide | |
45 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Homo sapiens | safinamide | |
580 | - |
isoform MAO-A, at pH 7.4, temperature not specified in the publication | Rattus norvegicus | safinamide |