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Literature summary for 1.4.3.4 extracted from

  • Wang, J.; Edmondson, D.E.
    2H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme (2011), Biochemistry, 50, 7710-7717.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
Harmane reversible enzyme-specific inhibitor Rattus norvegicus
methylene blue reversible enzyme-specific inhibitor Rattus norvegicus
pirlindole mesylate reversible enzyme-specific inhibitor Rattus norvegicus
tetrindole mesylate reversible enzyme-specific inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.034
-
 1-(4-bromophenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.054
-
 1-(4-chlorophenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.055
-
 1-(4-methylphenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.08
-
 1-(4-methoxyphenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.174
-
 1-(4-fluorophenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.194
-
 1-[4-(trifluoromethyl)phenyl]methanamine at pH 7.5 and 25°C Rattus norvegicus
0.2111
-
 benzylamine at pH 7.5 and 25°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
 Rattus norvegicus 5741
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
benzylamine + H2O + O2 Rattus norvegicus
-
 benzaldehyde + NH3 + H2O2
-
 ?
kynuramine + H2O + O2 Rattus norvegicus
-
 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(4-bromophenyl)methanamine + H2O + O2
-
 Rattus norvegicus 4-bromobenzaldehyde + NH3 + H2O2
-
 ?
1-(4-chlorophenyl)methanamine + H2O + O2
-
 Rattus norvegicus 4-chlorobenzaldehyde + NH3 + H2O2
-
 ?
1-(4-fluorophenyl)methanamine + H2O + O2
-
 Rattus norvegicus 4-fluorobenzaldehyde + NH3 + H2O2
-
 ?
1-(4-methoxyphenyl)methanamine + H2O + O2
-
 Rattus norvegicus 4-methoxybenzaldehyde + NH3 + H2O2
-
 ?
1-(4-methylphenyl)methanamine + H2O + O2
-
 Rattus norvegicus 4-methylbenzaldehyde + NH3 + H2O2
-
 ?
1-[4-(trifluoromethyl)phenyl]methanamine + H2O + O2
-
 Rattus norvegicus 4-(trifluoromethyl)benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
kynuramine + H2O + O2
-
 Rattus norvegicus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO A
-
 Rattus norvegicus
monoamine oxidase A
-
 Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.15
-
 1-(4-methoxyphenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.23
-
 1-(4-fluorophenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.27
-
 1-(4-methylphenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.33
-
 benzylamine at pH 7.5 and 25°C Rattus norvegicus
0.45
-
 1-(4-methoxyphenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
0.55
-
 benzylamine at pH 9.0 and 25°C Rattus norvegicus
0.73
-
 1-(4-chlorophenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
0.8
-
 1-(4-methylphenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
0.98
-
 1-(4-fluorophenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
1.03
-
 1-(4-bromophenyl)methanamine at pH 7.5 and 25°C Rattus norvegicus
2
-
 1-(4-chlorophenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
2.85
-
 1-(4-bromophenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
5.57
-
 1-[4-(trifluoromethyl)phenyl]methanamine at pH 7.5 and 25°C Rattus norvegicus
13.52
-
 1-[4-(trifluoromethyl)phenyl]methanamine at pH 9.0 and 25°C Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000026
-
 methylene blue at pH 7.5 and 25°C Rattus norvegicus
0.00075
-
 Harmane at pH 7.5 and 25°C Rattus norvegicus
0.00077
-
 pirlindole mesylate at pH 7.5 and 25°C Rattus norvegicus
0.0036
-
 tetrindole mesylate at pH 7.5 and 25°C Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme is important in the regulation of serotonin and dopamine levels Rattus norvegicus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
13
-
 benzylamine at pH 9.0 and 25°C Rattus norvegicus
38
-
 1-(4-fluorophenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
100
-
 1-(4-methoxyphenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
223
-
 1-(4-chlorophenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
326
-
 1-(4-bromophenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
347
-
 1-(4-methylphenyl)methanamine at pH 9.0 and 25°C Rattus norvegicus
381
-
 1-[4-(trifluoromethyl)phenyl]methanamine at pH 9.0 and 25°C Rattus norvegicus