Cloned (Comment) | Organism |
---|---|
expression of MAO-A and MAO-B in baculovirus infected BTI insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(N-methylthiocarbamoyl)-3-(3-methoxyphenyl)-4,5-dihydropyrazole | - |
Homo sapiens | |
1-(N-methylthiocarbamoyl)-3-(3-methylphenyl)-4,5-dihydropyrazole | - |
Homo sapiens | |
1-(N-methylthiocarbamoyl)-3-(4-chlorophenyl)-4-methyl-4,5-dihydropyrazole | - |
Homo sapiens | |
1-(N-methylthiocarbamoyl)-3-(4-fluorophenyl)-4,5-dihydropyrazole | - |
Homo sapiens | |
1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazole | - |
Homo sapiens | |
1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole | - |
Homo sapiens | |
1-(N-methylthiocarbamoyl)-3-(4-methylphenyl)-4,5-dihydropyrazole | - |
Homo sapiens | |
1-thiocarbamoyl-3-(4-methoxyphenyl)-4,5-dihydropyrazole | - |
Homo sapiens | |
1-thiocarbamoyl-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole | - |
Homo sapiens | |
1-thiocarbamoyl-3-(4-methylphenyl)-4,5-dihydropyrazole | - |
Homo sapiens | |
Clorgyline | - |
Homo sapiens | |
Iproniazide | - |
Homo sapiens | |
moclobemide | - |
Homo sapiens | |
additional information | synthesis of 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives and evaluation of their monoamine oxidase inhibitory activity, ligand docking and mechanism of inhibition, molecular modelling, overview. Comparison with 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole and 2-thiazolyl hydrazones, overview. No or poor inhibition of MAO-A by all compounds tested, no inhibition of MAO-B by compounds 1-thiocarbamoyl-3-(4-fluorophenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(3-methylphenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(2-methylphenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(3-methoxyphenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(2,4-dichlorophenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(thiophen-2-yl)-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(2-methylphenyl)-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(thiophen-2-yl)-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(4-fluorophenyl)-4-methyl-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(4-fluorophenyl)-4-methyl-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(4-methylphenyl)-4-methyl-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(4-methylphenyl)-4-methyl-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-phenyl-4-methyl-4,5-dihydropyrazole, 1-thiocarbamoyl-3-phenyl-4-methyl-4,5-dihydropyrazole, and 1-thiocarbamoyl-3-(4-chlorophenyl)-4-methyl-4,5-dihydropyrazole | Homo sapiens | |
R-(-)-deprenyl | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phenylethylamine + H2O + O2 | Homo sapiens | - |
? | - |
? | |
dopamine + H2O + O2 | Homo sapiens | - |
? | - |
? | |
epinephrine + H2O + O2 | Homo sapiens | - |
? | - |
? | |
norepinephrine + H2O + O2 | Homo sapiens | - |
? | - |
? | |
serotonin + H2O + O2 | Homo sapiens | - |
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phenylethylamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
4-tyramine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
dopamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
epinephrine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
norepinephrine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
serotonin + H2O + O2 | - |
Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
MAO-B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0137 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazole | |
0.0155 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-thiocarbamoyl-3-(4-methoxyphenyl)-4,5-dihydropyrazole | |
0.0168 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-(N-methylthiocarbamoyl)-3-(4-methylphenyl)-4,5-dihydropyrazole | |
0.0181 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-thiocarbamoyl-3-(4-methylphenyl)-4,5-dihydropyrazole | |
0.0348 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-(N-methylthiocarbamoyl)-3-(4-chlorophenyl)-4-methyl-4,5-dihydropyrazole | |
0.0494 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole | |
0.051 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-(N-methylthiocarbamoyl)-3-(4-fluorophenyl)-4,5-dihydropyrazole | |
0.0534 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-(N-methylthiocarbamoyl)-3-(3-methylphenyl)-4,5-dihydropyrazole | |
0.0713 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-(N-methylthiocarbamoyl)-3-(3-methoxyphenyl)-4,5-dihydropyrazole | |
0.0846 | - |
pH 7.4, 37°C, recombinant MAO-B | Homo sapiens | 1-thiocarbamoyl-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole |
General Information | Comment | Organism |
---|---|---|
metabolism | monoamine oxidase are key role enzymes in the catabolism of amines like dopamine, norepinephrine, epinephrine, serotonin, and 2-phenylethylamine | Homo sapiens |