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Literature summary for 1.4.3.4 extracted from

  • Goekhan-Kelekci, N.; Simsek, O.O.; Ercan, A.; Yelekci, K.; Sahin, Z.S.; I?ik, S.; Ucar, G.; Bilgin, A.A.
    Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors (2009), Bioorg. Med. Chem., 17, 6761-6772.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
-
 Rattus norvegicus
3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
-
 Rattus norvegicus
cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
moclobemide
-
 Rattus norvegicus
additional information synthesis and molecular modeling of some hexahydroindazole derivatives as potent monoamine oxidase inhibitors, overview Rattus norvegicus
selegiline
-
 Rattus norvegicus
trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-tyramine + H2O + O2
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Rattus norvegicus
MAO-B
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00027
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00042
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00053
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0011
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
0.00127
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
0.00136
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
0.0017
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.002
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0021
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
0.0025
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0026
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00273
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0028
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0029
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00318
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00358
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0088
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0201
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0312
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0695
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0707
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0931
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol