Literature summary for 1.4.3.4 extracted from

Real, C.; Seif, I.; Adrien, J.; Escourrou, P.
Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A (2009), Respir. Physiol. Neurobiol., 168, 230-238.

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Protein Variants

Protein Variants	Comment	Organism
additional information	construction of transgenic mice lacking monoamine oxidase A. The mice exhibit about 3fold higher rates of central sleep apnea than wild-types, linked to enhanced 5-hydroxytryptamine levels. Acute ondansetron and fluoxetine, and 13-day chronic fluoxetine decreas by 80% the total apnea index in the mutant mice during non-rapid eye movement sleep, with no statistically significant effect on apnea in C3H mice. Our study shows that both drugs reduce the frequency of apneic episodes attributable to increased monoamine levels in this model of MAOA deficiency, phenotypes, detailed overview	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
MAO-A	-	Mus musculus
monoamine oxidase A	-	Mus musculus

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Release 2023.1 (January 2023)